IL10 released by a new inflammation-regulated lentiviral system efficiently attenuates zymosan-induced arthritis.

@article{Garaulet2013IL10RB,
  title={IL10 released by a new inflammation-regulated lentiviral system efficiently attenuates zymosan-induced arthritis.},
  author={Guillermo Garaulet and Arantzazu Alfranca and Mar{\'i}a Torrente and Amelia Escolano and Raquel L{\'o}pez-Fontal and Sonsoles Hortelano and Juan Miguel Redondo and Ant{\^o}nio Jos{\'e} Arraiz Rodriguez},
  journal={Molecular therapy : the journal of the American Society of Gene Therapy},
  year={2013},
  volume={21 1},
  pages={119-30}
}
Administration of anti-inflammatory cytokines is a common therapeutic strategy in chronic inflammatory diseases. Gene therapy is an efficient method for delivering therapeutic molecules to target cells. Expression of the cell adhesion molecule E-selectin (ESEL), which is expressed in the early stages of inflammation, is controlled by proinflammatory cytokines, making its promoter a good candidate for the design of inflammation-regulated gene therapy vectors. This study describes an ESEL… CONTINUE READING
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