IL-TIF/IL-22: genomic organization and mapping of the human and mouse genes

  title={IL-TIF/IL-22: genomic organization and mapping of the human and mouse genes},
  author={Laure Dumoutier and E Van Roost and Genevi{\`e}ve Ameye and Lucienne Michaux and J-C Renauld},
  journal={Genes and Immunity},
IL-TIF is a new cytokine originally identified as a gene induced by IL-9 in murine T lymphocytes, and showing 22% amino acid identity with IL-10. Here, we report the sequence and organization of the mouse and human IL-TIF genes, which both consist of 6 exons spreading over approximately 6 Kb. The IL-TIF gene is a single copy gene in humans, and is located on chromosome 12q15, at 90 Kb from the IFNγ gene, and at 27 Kb from the AK155 gene, which codes for another IL-10-related cytokine. In the… CONTINUE READING


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