IL-9 promotes Th17 cell migration into the central nervous system via CC chemokine ligand-20 produced by astrocytes.

@article{Zhou2011IL9PT,
  title={IL-9 promotes Th17 cell migration into the central nervous system via CC chemokine ligand-20 produced by astrocytes.},
  author={Yan Zhou and Yoshifumi Sonobe and Tomohiko Akahori and Shijie Jin and Jun Kawanokuchi and Mariko Noda and Yoichiro Iwakura and Tetsuya Mizuno and Akio Suzumura},
  journal={Journal of immunology},
  year={2011},
  volume={186 7},
  pages={4415-21}
}
Newly discovered IL-9-producing helper T cells (Th9) reportedly exert both aggravating and suppressive roles on experimental autoimmune encephalomyelitis, an animal model of multiple sclerosis. However, it is still unclear whether Th9 is a distinct Th cell subset and how IL-9 functions in the CNS. In this study, we show that IL-9 is produced by naive CD4(+) T cells that were stimulated with anti-CD3 and anti-CD28 Abs under the conditions of Th2-, inducible regulatory T cell-, Th17-, and Th9… CONTINUE READING

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