IL-9 inhibits HTB-72 melanoma cell growth through upregulation of p21 and TRAIL.

@article{Fang2015IL9IH,
  title={IL-9 inhibits HTB-72 melanoma cell growth through upregulation of p21 and TRAIL.},
  author={Yujiang Fang and Xuhui Chen and Qian Bai and Chenglu Qin and Abdimalik O Mohamud and Ziwen Zhu and Tyler W Ball and Christina Ruth and Dylan R Newcomer and Elizabeth J Herrick and Michael B Nicholl},
  journal={Journal of surgical oncology},
  year={2015},
  volume={111 8},
  pages={
          969-74
        }
}
BACKGROUND IL-9 is a pleiotropic cytokine produced mainly by Th9 cells. IL-9 may have an anti-proliferative role in murine melanoma, however, its effect on human melanoma is unknown. METHODS We examined the effects of IL-9 on proliferation and apoptosis in four human melanoma cell lines, HTB-65, HTB-72, CRL-11147, and SK-Mel-5. Clonogenic assay, PCNA staining, Quick Cell Proliferation assay, TUNEL staining and caspase-3 activity assay were used to assess proliferation and apoptosis, as… CONTINUE READING

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