IL-9-deficient mice establish fundamental roles for IL-9 in pulmonary mastocytosis and goblet cell hyperplasia but not T cell development.

Abstract

Interleukin-9 is a cytokine produced by Th2 cells and is a candidate gene for asthma and atopy. We have generated IL-9-deficient mice to delineate the specific roles of IL-9 in Th2 responses. Using a pulmonary granuloma model, we have demonstrated a distinct requirement for IL-9 in the rapid and robust generation of pulmonary goblet cell hyperplasia and mastocytosis in response to lung challenge. In contrast, eosinophilia and granuloma formation were not affected. IL-9 was not required for T cell development or differentiation, the generation of naive or antigen-driven antibody responses, or the expulsion of the intestinal parasitic nematode Nippostrongylus brasiliensis. Thus, deletion of IL-9 manifests as a highly defined phenotype in Th2 responses modulating mucus production and mast cell proliferation.

050100150'02'04'06'08'10'12'14'16
Citations per Year

1,500 Citations

Semantic Scholar estimates that this publication has 1,500 citations based on the available data.

See our FAQ for additional information.

Cite this paper

@article{Townsend2000IL9deficientME, title={IL-9-deficient mice establish fundamental roles for IL-9 in pulmonary mastocytosis and goblet cell hyperplasia but not T cell development.}, author={Joanne M Townsend and G P Fallon and John D. Matthews and Philippa Smith and E H Jolin and Neil McKenzie}, journal={Immunity}, year={2000}, volume={13 4}, pages={573-83} }