IL-9 as a mediator of Th17-driven inflammatory disease

  title={IL-9 as a mediator of Th17-driven inflammatory disease},
  author={Elizabeth C. Nowak and Casey T Weaver and Henrietta Turner and Sakhina Begum-Haque and Burkhard Becher and Bettina Schreiner and Anthony J Coyle and Lloyd H. Kasper and Randolph J. Noelle},
  booktitle={The Journal of experimental medicine},
We report that like other T cells cultured in the presence of transforming growth factor (TGF) beta, Th17 cells also produce interleukin (IL) 9. Th17 cells generated in vitro with IL-6 and TGF-beta as well as purified ex vivo Th17 cells both produced IL-9. To determine if IL-9 has functional consequences in Th17-mediated inflammatory disease, we evaluated the role of IL-9 in the development and progression of experimental autoimmune encephalomyelitis, a mouse model of multiple sclerosis. The… CONTINUE READING
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IL-4 inhibits TGF-beta-induced Foxp3+ T cells and, together with TGF-beta, generates IL-9+ IL-10+ Foxp3 effector T cells

  • V. Dardalhon, A. Awasthi, +7 authors I. C. Ho
  • Nat. Immunol
  • 2008
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