IL-9 and IL-13 production by activated mast cells is strongly enhanced in the presence of lipopolysaccharide: NF-kappa B is decisively involved in the expression of IL-9.

@article{Stassen2001IL9AI,
  title={IL-9 and IL-13 production by activated mast cells is strongly enhanced in the presence of lipopolysaccharide: NF-kappa B is decisively involved in the expression of IL-9.},
  author={M. Janna Stassen and Cynthia Mueller and Martina Arnold and Lothar H{\"u}ltner and Stefan Klein-Hessling and Christine Neudoerfl and Tanja Reineke and E. Serfling and Estelle Schmitt},
  journal={Journal of immunology},
  year={2001},
  volume={166 7},
  pages={4391-8}
}
Mast cells, due to their ability to produce a large panel of mediators and cytokines, participate in a variety of processes in adaptive and innate immunity. Herein we report that in primary murine bone marrow-derived mast cells activated with ionomycin or IgE-Ag the bacterial endotoxin LPS strongly enhances the expression of IL-9 and IL-13, but not IL-4. This costimulatory effect of LPS is absent in activated mast cells derived from the LPS-hyporesponsive mouse strain BALB/c-LPS(d), although in… CONTINUE READING

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