IL-9 and IL-13 induce mucous cell metaplasia that is reduced by IFN-gamma in a Bax-mediated pathway.

Abstract

One of the major aspects of airway remodeling in asthma is the development of mucous cell metaplasia (MCM). The role of cytokines in the generation and resolution of MCM has been studied in mice and in isolated airway epithelial cells in culture. However, studies using organ cultures that keep the tubular structure of the airways intact and allow studies in… (More)

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@article{Xiang2008IL9AI, title={IL-9 and IL-13 induce mucous cell metaplasia that is reduced by IFN-gamma in a Bax-mediated pathway.}, author={Jialing Xiang and Jules Rir-Sim-Ah and Yohannes Tesfaigzi}, journal={American journal of respiratory cell and molecular biology}, year={2008}, volume={38 3}, pages={310-7} }