IL-9 Regulates Allergen-Specific Th1 Responses in Allergic Contact Dermatitis

  title={IL-9 Regulates Allergen-Specific Th1 Responses in Allergic Contact Dermatitis},
  author={Juan Liu and Erin M Harberts and Antonella Tammaro and Nicholas Girardi and Renata B. Filler and Rita Fishelevich and Angela U Temann and Paula Licona-Limon and Michael Girardi and Richard A Flavell and Anthony A. Gaspari},
  booktitle={The Journal of investigative dermatology},
The cytokine IL-9, derived primarily from T-helper 9 (Th9) lymphocytes, promotes expansion of the Th2 subset and is implicated in the mechanisms of allergic asthma. We hypothesize that IL-9 also has a role in human allergic contact dermatitis (ACD). To investigate this hypothesis, skin biopsy specimens of positive patch-test sites from non-atopic patients were assayed using quantitative PCR and immunohistochemistry. The cytokines IFN-γ, IL-4, IL-17A, IL-9, and PU.1, a Th9 associated… CONTINUE READING
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