IL-8 induces expression of matrix metalloproteinases, cell cycle and pro-apoptotic proteins, and cell death in cultured neurons.

@article{Thirumangalakudi2007IL8IE,
  title={IL-8 induces expression of matrix metalloproteinases, cell cycle and pro-apoptotic proteins, and cell death in cultured neurons.},
  author={Lakshmi Thirumangalakudi and Linda X Yin and Haripriya Vittal Rao and Paula Grammas},
  journal={Journal of Alzheimer's disease : JAD},
  year={2007},
  volume={11 3},
  pages={305-11}
}
Neuronal cell loss is a critical feature of age-related neurodegenerative diseases such as Alzheimer's disease (AD). In the AD brain, a marked increase in pro-inflammatory cytokines and chemokines, including IL-8, has been documented. The objective of this study was to determine the effect of IL-8 on cell viability and expression of neurotoxic, apoptotic, and cell cycle proteins in cultured neurons. Incubation of cultured neurons with IL-8 for 24 h resulted in neuronal cell death. RT-PCR… CONTINUE READING

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