IL-8 induces a transient arrest of rolling eosinophils on human endothelial cells.

@article{Ulfman2001IL8IA,
  title={IL-8 induces a transient arrest of rolling eosinophils on human endothelial cells.},
  author={Laurien H. Ulfman and Dianne P. H. Joosten and Joke A van der Linden and Jan-Willem J Lammers and Jaap J Zwaginga and Leo Koenderman},
  journal={Journal of immunology},
  year={2001},
  volume={166 1},
  pages={588-95}
}
Eosinophils exhibit a rolling interaction with E-selectin-expressing endothelium, and need to be activated by inflammatory mediators to firmly adhere to this surface. This study shows that IL-8 induces a transient arrest of unprimed eosinophils that roll on E-selectin present on TNF-alpha-activated HUVEC in an in vitro flow chamber. This process was antagonized by neutralizing Abs directed against IL-8 showing the specificity of the IL-8 effect. Furthermore, blocking Abs against both alpha(4… CONTINUE READING

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