IL-8 induces a transient arrest of rolling eosinophils on human endothelial cells.

@article{Ulfman2001IL8IA,
  title={IL-8 induces a transient arrest of rolling eosinophils on human endothelial cells.},
  author={Laurien H. Ulfman and Dianne P H Joosten and Joke A van der Linden and Jan W.J. Lammers and Jaap J Zwaginga and Leo Koenderman},
  journal={Journal of immunology},
  year={2001},
  volume={166 1},
  pages={
          588-95
        }
}
Eosinophils exhibit a rolling interaction with E-selectin-expressing endothelium, and need to be activated by inflammatory mediators to firmly adhere to this surface. This study shows that IL-8 induces a transient arrest of unprimed eosinophils that roll on E-selectin present on TNF-alpha-activated HUVEC in an in vitro flow chamber. This process was antagonized by neutralizing Abs directed against IL-8 showing the specificity of the IL-8 effect. Furthermore, blocking Abs against both alpha(4… CONTINUE READING

Citations

Publications citing this paper.
SHOWING 1-10 OF 14 CITATIONS

Epithelial folliculin enhances airway inflammation in aspirin-exacerbated respiratory disease.

  • Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology
  • 2018

Autophagy mechanisms in sputum and peripheral blood cells of patients with severe asthma: a new therapeutic target.

  • Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology
  • 2016

References

Publications referenced by this paper.
SHOWING 1-10 OF 46 REFERENCES

Freezing adhesion molecules in a state of high-avidity binding blocks eosinophil migration

  • The Journal of experimental medicine
  • 1993
VIEW 4 EXCERPTS
HIGHLY INFLUENTIAL

VLA-4 (a4b1) engagement defines a novel activation pathway for b2 integrin-dependent leukocyte adhesion involving the urokinase receptor. Blood 96:506

A. E. May, F. J. Neumann, A. Schomig, K. T. Preissner
  • The Journal of Immunology
  • 2000
VIEW 1 EXCERPT

Similar Papers