IL-8 -251T/A and IL-12B 1188A/C polymorphisms are associated with gout in a Chinese male population.

@article{Liu2013IL8A,
  title={IL-8 -251T/A and IL-12B 1188A/C polymorphisms are associated with gout in a Chinese male population.},
  author={Shan Liu and Congcong Yin and Nan Chu and Lin Han and Chu-hua Li},
  journal={Scandinavian journal of rheumatology},
  year={2013},
  volume={42 2},
  pages={150-8}
}
OBJECTIVES Gout is caused by monosodium urate (MSU) crystal-induced inflammation of the joints and periarticular tissues. MSU crystals activate NALP3 and mediate interleukin (IL)-1β generation from its inactive pro-form, resulting in cellular activation and an IL-8-mediated neutrophil influx into the joint. IL-8 and IL-12 are important chemokines related to the initiation and amplification of acute and chronic inflammatory processes. In this study, we investigated whether the IL-8 -251T/A and… CONTINUE READING
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