IL-7Ralpha expression on CD4+ T lymphocytes decreases with HIV disease progression and inversely correlates with immune activation.

@article{Koesters2006IL7RalphaEO,
  title={IL-7Ralpha expression on CD4+ T lymphocytes decreases with HIV disease progression and inversely correlates with immune activation.},
  author={Sandra A Koesters and Judie B. Alimonti and Charles Wachihi and Lucy Matu and Omu Anzala and Joshua Kimani and Joanne E. Embree and Francis Allan Plummer and Keith R Fowke},
  journal={European journal of immunology},
  year={2006},
  volume={36 2},
  pages={336-44}
}
Many factors can influence the rate of HIV disease progression, including those that maintain T cell homeostasis. One key homeostatic regulator is the IL-7 receptor (IL-7R). Previous studies have shown IL-7R expression levels decrease in HIV infection, but effects on memory subtypes, CD4(+) T cells, and cell function have not been explored. The present study examined the expression of the IL-7Ralpha chain on naïve and memory T lymphocyte subsets of both HIV-positive and HIV-negative individuals… CONTINUE READING

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