IL-7 promotes the survival and maturation but not differentiation of human post-thymic CD4+ T cells.

@article{Hassan1998IL7PT,
  title={IL-7 promotes the survival and maturation but not differentiation of human post-thymic CD4+ T cells.},
  author={Jaythoon Hassan and Denis J. Reen},
  journal={European journal of immunology},
  year={1998},
  volume={28 10},
  pages={3057-65}
}
This study examines the influence of IL-7 on post-thymic CD4+ T cells using cord blood as a model system. Survival of naive cord blood T cells in the presence of IL-7 alone was significantly prolonged by up-regulating bcl-2, thereby preventing apoptosis while maintaining maximal cell viability. Cultures without IL-7 showed high rates of apoptosis resulting in 50% cell death by day 5 of culture. Upon phorbol 12-myristate 13-acetate + ionomycin stimulation, accumulation of cytoplasmic IL-2 was… CONTINUE READING