IL-7 promotes T cell viability, trafficking, and functionality and improves survival in sepsis.

  title={IL-7 promotes T cell viability, trafficking, and functionality and improves survival in sepsis.},
  author={Jacqueline Unsinger and Margaret G. McGlynn and Kevin Richard Kasten and Andrew S. Hoekzema and Eizo Watanabe and Jared T. Muenzer and Jacquelyn S. McDonough and Johannes Tschoep and Thomas A. Ferguson and Jonathan E. McDunn and Michel Morre and David A Hildeman and Charles C Caldwell and Richard S Hotchkiss},
  journal={Journal of immunology},
  volume={184 7},
Sepsis is a highly lethal disorder characterized by widespread apoptosis-induced depletion of immune cells and the development of a profound immunosuppressive state. IL-7 is a potent antiapoptotic cytokine that enhances immune effector cell function and is essential for lymphocyte survival. In this study, recombinant human IL-7 (rhIL-7) efficacy and potential mechanisms of action were tested in a murine peritonitis model. Studies at two independent laboratories showed that rhIL-7 markedly… CONTINUE READING
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