IL-7 mRNA is not overexpressed in mycosis fungoides and pleomorphic T-cell lymphoma and is unlikely to be an autocrine growth factor in vivo

@article{Asadullah1996IL7MI,
  title={IL-7 mRNA is not overexpressed in mycosis fungoides and pleomorphic T-cell lymphoma and is unlikely to be an autocrine growth factor in vivo},
  author={Khusru Asadullah and Antje Haeu\ssler and Markus Friedrich and Angela Siegling and Sylvia Olaizola-Horn and Uwe Trefzer and H P Volk and Wolfram Sterry},
  journal={Archives of Dermatological Research},
  year={1996},
  volume={289},
  pages={9-13}
}
Interleukin-7 (IL-7) is thought to be a growth factor for cutaneous T-cell lymphoma (CTCL) since it has been shown that IL-7 transgenic mice develop a cutaneous disorder characterized by enhanced T-cell proliferation with progression to malignancy and that in vitro growth of Sézary cell lines is IL-7 dependent. However, no direct in vivo evidence exists for the involvement of IL-7 in the pathogenesis of CTCL. Therefore, we examined IL-7 mRNA expression in skin biopsies from patients with… CONTINUE READING

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