IL-7 is expressed and secreted by human skeletal muscle cells.
@article{Haugen2010IL7IE, title={IL-7 is expressed and secreted by human skeletal muscle cells.}, author={Fred Haugen and Frode Norheim and Henrik Lian and Andreas J. Wensaas and Svein Dueland and Ole Aleksander Berg and Ane Funderud and Bj{\o}rn S. Sk{\aa}lhegg and Truls Raastad and Christian A. Drevon}, journal={American journal of physiology. Cell physiology}, year={2010}, volume={298 4}, pages={ C807-16 } }
In addition to generating movement, skeletal muscle may have a function as a secretory organ. The aim of the present study was to identify novel proteins with signaling capabilities secreted from skeletal muscle cells. IL-7 was detected in media conditioned by primary cultures of human myotubes differentiated from satellite cells, and concentrations increased with incubation time. By immunoblotting and real-time RT-PCR IL-7 expression was confirmed at both protein and mRNA levels. Furthermore…
176 Citations
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Cell metabolism
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Biology
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Calprotectin is released from human skeletal muscle tissue during exercise
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Biology, Medicine
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IL‐6 infusion and muscle contractions induce expression of S 100A8 and S100A9 in skeletal muscle, however, IL‐6 alone is not a sufficient stimulus to facilitate release of calprotectin from skeletal muscle.
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Biology, Medicine
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Biology
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It is shown that myostatin, a TGF-β member, signals satellite cell quiescence and also negatively regulates satellite cell self-renewal.
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Biology
American journal of physiology. Endocrinology and metabolism
The aim of the present study was to examine whether IL-6 and TNF-alpha are expressed in, and released from, human skeletal muscle during exercise. We hypothesized that the skeletal muscle will…
THIS ARTICLE HAS BEEN RETRACTED Exercise induces interleukin‐8 expression in human skeletal muscle
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Biology
The Journal of physiology
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Developmental dynamics : an official publication of the American Association of Anatomists
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The Journal of Biological Chemistry
Observations provide a more complete dissection of molecular events by which increased local expression of a growth factor in mature skeletal muscle fibers extends replicative life span of primary stem cells than previously known.