IL-7 is a potent and proviral strain-specific inducer of latent HIV-1 cellular reservoirs of infected individuals on virally suppressive HAART.

@article{Wang2005IL7IA,
  title={IL-7 is a potent and proviral strain-specific inducer of latent HIV-1 cellular reservoirs of infected individuals on virally suppressive HAART.},
  author={Feng-xiang Wang and Yan Xu and Julie N Sullivan and Emily Souder and Elias G. Argyris and Edward A. Acheampong and Jaime Fisher and Mar{\'i}a del Carmen Sierra and Michael M. Thomson and Rafael N{\'a}jera and Ian Frank and Joseph Kulkosky and Roger J. Pomerantz and Giuseppe Nunnari},
  journal={The Journal of clinical investigation},
  year={2005},
  volume={115 1},
  pages={128-37}
}
The persistence of HIV-1 in virally suppressed infected individuals on highly active antiretroviral therapy (HAART) remains a major therapeutic problem. The use of cytokines has been envisioned as an additional therapeutic strategy to stimulate latent proviruses in these individuals. Immune activation therapy using IL-2 has shown some promise. In the present study, we found that IL-7 was significantly more effective at enhancing HIV-1 proviral reactivation than either IL-2 alone or IL-2… CONTINUE READING

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References

Publications referenced by this paper.
Showing 1-10 of 45 references

Long-term follow-up studies confirm the stability of the latent reservoir for HIV-1 in resting CD4+ T cells

Siliciano, J.D
Nat. Med • 2003
View 6 Excerpts
Highly Influenced

Effects of interleukin-2 plus highly active antiretroviral therapy on HIV-1 replication and proviral DNA (COSMIC trial)

Stellbrink, H.J
2002
View 4 Excerpts
Highly Influenced

Effect of interleukin-2 on the pool of latently infected, resting CD4+ T cells in HIV-1-infected patients receiving highly active anti-retroviral therapy

Chun, T.W
Nat. Med • 1999
View 4 Excerpts
Highly Influenced

The neighbor-joining method: a new method for reconstructing phylogenetic trees.

Molecular biology and evolution • 1987
View 3 Excerpts
Highly Influenced

L-7 stimulates T cell renewal without increasing viral replication in simian immunodeficiency virus-infected macaques

Nugeyre, M.T
J. Immunol • 2003
View 2 Excerpts

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