IL-7 induces rapid clathrin-mediated internalization and JAK3-dependent degradation of IL-7Ralpha in T cells.

@article{Henriques2010IL7IR,
  title={IL-7 induces rapid clathrin-mediated internalization and JAK3-dependent degradation of IL-7Ralpha in T cells.},
  author={Catarina M Henriques and Jos{\'e} Rino and Robert J B Nibbs and Gerard J Graham and Jo{\~a}o T Barata},
  journal={Blood},
  year={2010},
  volume={115 16},
  pages={3269-77}
}
Interleukin-7 (IL-7) is an essential cytokine for T-cell development and homeostasis. It is well established that IL-7 promotes the transcriptional down-regulation of IL7RA, leading to decreased IL-7Ralpha surface expression. However, it is currently unknown whether IL-7 regulates the intracellular trafficking and early turnover of its receptor on ligand binding. Here, we show that, in steady-state T cells, IL-7Ralpha is slowly internalized and degraded while a significant fraction recycles… CONTINUE READING
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