IL-7 induces expression and activation of integrin α4β7 promoting naive T-cell homing to the intestinal mucosa.

@article{Cimbro2012IL7IE,
  title={IL-7 induces expression and activation of integrin α4β7 promoting naive T-cell homing to the intestinal mucosa.},
  author={Raffaello Cimbro and Lia Vassena and James Arthos and Claudia Cicala and John H Kehrl and Chung Park and Irini Sereti and Michael M. Lederman and Anthony S. Fauci and Paolo Lusso},
  journal={Blood},
  year={2012},
  volume={120 13},
  pages={2610-9}
}
Interleukin-7 (IL-7) is a nonredundant cytokine that plays a critical role in T-cell homeostasis and promotes immunologic reconstitution in lymphopenic hosts. Here, we show that IL-7, at doses that reflect suprahomeostatic concentrations achieved in lymphopenic hosts, is a potent and selective inducer of the gut-homing integrin α4β7 in human T cells, as documented both ex vivo and in vivo in patients enrolled in a clinical trial of IL-7 treatment. Induction of α4β7 by IL-7 occurs primarily in… CONTINUE READING
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The Journal of allergy and clinical immunology • 2009

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