IL-7 in human health and disease.

@article{Lundstrm2012IL7IH,
  title={IL-7 in human health and disease.},
  author={Wangko Lundstr{\"o}m and Natasha M. Fewkes and Crystal L Mackall},
  journal={Seminars in immunology},
  year={2012},
  volume={24 3},
  pages={218-24}
}
IL-7 plays many essential roles in human health and disease. Congenital deficiencies in IL-7 signaling result in profound immunodeficiency, polymorphisms in IL7Rα modulate susceptibility to autoimmune disease, and acquired somatic activating mutations in IL7Rα contribute to neoplastic transformation in B cell and T cell leukemia. In response to lymphopenia, IL-7 accumulates to supranormal levels, which alters T cell homeostasis by augmenting T cell reactivity toward self and cognate antigens… CONTINUE READING
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