IL-7 differentially regulates cell cycle progression and HIV-1-based vector infection in neonatal and adult CD4+ T cells.

@article{Dardalhon2001IL7DR,
  title={IL-7 differentially regulates cell cycle progression and HIV-1-based vector infection in neonatal and adult CD4+ T cells.},
  author={Val{\'e}rie Dardalhon and Sara Jaleco and Sandrina Kinet and Bram Herpers and Marcos Steinberg and C. Ferrand and D Froger and C. Leveau and Pierre Tiberghien and Pierre Charneau and Nelly Noraz and Naomi Taylor},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2001},
  volume={98 16},
  pages={
          9277-82
        }
}
Differences in the immunological reactivity of umbilical cord (UC) and adult peripheral blood (APB) T cells are poorly understood. Here, we show that IL-7, a cytokine involved in lymphoid homeostasis, has distinct regulatory effects on APB and UC lymphocytes. Neither naive nor memory APB CD4(+) cells proliferated in response to IL-7, whereas naive UC CD4(+) lymphocytes underwent multiple divisions. Nevertheless, both naive and memory IL-7-treated APB T cells progressed into the G(1b) phase of… CONTINUE READING

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