IL-7 administration to humans leads to expansion of CD8+ and CD4+ cells but a relative decrease of CD4+ T-regulatory cells.

@article{Rosenberg2006IL7AT,
  title={IL-7 administration to humans leads to expansion of CD8+ and CD4+ cells but a relative decrease of CD4+ T-regulatory cells.},
  author={Steven A Rosenberg and Claude Sport{\'e}s and Mojgan Ahmadzadeh and Terry J Fry and Lien T Ngo and Susan L. Schwarz and Maryalice Stetler-Stevenson and Kathleen E. Morton and Sharon A. Mavroukakis and Michel Morre and Renaud Buffet and Crystal L Mackall and Ronald E Gress},
  journal={Journal of immunotherapy},
  year={2006},
  volume={29 3},
  pages={313-9}
}
Lymphopenia is a serious consequence of HIV infection and the administration of cancer chemotherapeutic agents. Although growth factors can be administered to patients to increase circulating neutrophils, there is no effective method to stimulate CD8+ lymphocyte production in humans, in vivo. This report is the first to describe the administration of recombinant interleukin-7 to humans and demonstrates the ability of this cytokine to mediate selective increases in CD4+ and CD8+ lymphocytes… CONTINUE READING

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