IL-6 signaling SOCS critical for IL-12 host response to Toxoplasma gondii.

@article{Mirpuri2012IL6SS,
  title={IL-6 signaling SOCS critical for IL-12 host response to Toxoplasma gondii.},
  author={Julie Mirpuri and Felix O. Yarovinsky},
  journal={Future microbiology},
  year={2012},
  volume={7 1},
  pages={13-6}
}
SOCS are a family of proteins that play an important role in the negative regulation of the cytokine-JAK-STAT pathway. Socs3 deletion results in prolonged IL-6 signaling measured by STAT3 phosphorylation. A role for STAT3 and SOCS3 in the context of Toxoplasma gondii infection is of particular importance, because STAT3 appears to be a key target of T. gondii virulence factors. By utilizing LysM-cre Socs3(fl/fl) mice, the Hunter laboratory recently established that macrophage-specific SOCS3… CONTINUE READING