IL-6 promotes acute and chronic inflammatory disease in the absence of SOCS3

Abstract

The lack of expression of the suppressor of cytokine signalling-3 (SOCS3) or inactivation of the negative regulatory capacity of SOCS3 has been well documented in rheumatoid arthritis, viral hepatitis and cancer. The specific qualitative and quantitative consequences of SOCS3 deficiency on interleukin-6 (IL-6)-mediated pro- and anti-inflammatory responses… (More)
DOI: 10.1038/icb.2011.29

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