IL-6 produced by macrophages infected with Mycobacterium species suppresses T cell responses.

@article{Vanheyningen1997IL6PB,
  title={IL-6 produced by macrophages infected with Mycobacterium species suppresses T cell responses.},
  author={Tambryn K Vanheyningen and Helen L. Collins and David G Russell},
  journal={Journal of immunology},
  year={1997},
  volume={158 1},
  pages={330-7}
}
The ability of Mycobacterium bovis Calmette-Guérin bacillus-infected bone marrow-derived macrophages to process and present exogenously added Ags to T cells and stimulate their growth and production of IL-2 was examined. The infected macrophages were inhibited in their ability to activate T cells, and this inhibition could be transferred to uninfected macrophages with filtered supernatants from mycobacteria-infected macrophages. The inhibition was not due to decreases in macrophage viability… CONTINUE READING

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