IL-6 modulates hyperglycemia-induced changes of Na+ channel Beta-3 subunit expression by Schwann cells.

@article{Skundric2003IL6MH,
  title={IL-6 modulates hyperglycemia-induced changes of Na+ channel Beta-3 subunit expression by Schwann cells.},
  author={Dusanka S Skundric and Rujuan Dai and Philip Mataverde},
  journal={Annals of the New York Academy of Sciences},
  year={2003},
  volume={1005},
  pages={233-6}
}
Our data show the suppressive effect of hyperglycemia on expression of voltage-gated Na+ channel beta3 subunit by Schwann cells as well as the protection of beta3 expression by treatment with IL-6. Our findings have direct relevance for therapy of diabetic neuropathy.