IL-6-mediated environmental conditioning of defective Th1 differentiation dampens antitumour immune responses in old age

@inproceedings{Tsukamoto2015IL6mediatedEC,
  title={IL-6-mediated environmental conditioning of defective Th1 differentiation dampens antitumour immune responses in old age},
  author={Hirotake Tsukamoto and Satoru Senju and Keiko Matsumura and Susan L Swain and Yasuharu Nishimura},
  booktitle={Nature communications},
  year={2015}
}
Decline in immune function and inflammation concomitantly develop with ageing. Here we focus on the impact of this inflammatory environment on T cells, and demonstrate that in contrast to successful tumour elimination in young mice, replenishment of tumour-specific CD4(+) T cells fails to induce tumour regression in aged hosts. The impaired antitumour effect of CD4(+) T cells with their defective Th1 differentiation in an aged environment is restored by interleukin (IL)-6 blockade or IL-6… CONTINUE READING
Highly Cited
This paper has 34 citations. REVIEW CITATIONS

9 Figures & Tables

Topics

Statistics

02040201620172018
Citations per Year

Citation Velocity: 12

Averaging 12 citations per year over the last 3 years.

Learn more about how we calculate this metric in our FAQ.