IL-6 knockout mice exhibit resistance to stress-induced development of depression-like behaviors.

@article{Chourbaji2006IL6KM,
  title={IL-6 knockout mice exhibit resistance to stress-induced development of depression-like behaviors.},
  author={Sabine Chourbaji and Alexandre Urani and Ioana Monica Inta and Carles Sanchis-Segura and Christiane Brandwein and Mathias Zink and Markus Schwaninger and Peter Gass},
  journal={Neurobiology of disease},
  year={2006},
  volume={23 3},
  pages={587-94}
}
Cytokine-dependent mechanisms in the CNS have been implicated in the pathogenesis of depression. Interleukin-6 is upregulated in depressed patients and dowregulated by antidepressants. It is, however, unknown whether IL-6 is involved in the pathogenesis of depression. We subjected IL-6-deficient mice (IL-6(-/-)) to depression-related tests (learned helplessness, forced swimming, tail suspension, sucrose preference). We also investigated IL-6 in the hippocampus of stressed wild-type mice. IL-6… CONTINUE READING