IL-6 is present in beta and alpha cells in human pancreatic islets: Expression is reduced in subjects with type 1 diabetes.

@article{Rajendran2019IL6IP,
  title={IL-6 is present in beta and alpha cells in human pancreatic islets: Expression is reduced in subjects with type 1 diabetes.},
  author={S. Rajendran and Florence Anquetil and Estefania Quesada-Masachs and Madeleine Graef and Nathaly Gonz{\'a}lez and Sara McArdle and Tiffany Chu and L. Krogvold and K. Dahl-J{\o}rgensen and M. V. von Herrath},
  journal={Clinical immunology},
  year={2019},
  pages={
          108320
        }
}
IL-6 is a pro-inflammatory cytokine upregulated in some autoimmune diseases. The role of IL-6 in the development of type 1 diabetes (T1D) is unclear. Clinical studies are investigating whether tocilizumab (anti-IL-6 receptor) can help preserve beta cell function in patients recently diagnosed with T1D. However, in some rodent models and isolated human islets, IL-6 has been found to have a protective role for beta cells by reducing oxidative stress. Hence, we systematically investigated local… Expand
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