IL-6 is not essential for exercise-induced increases in glucose uptake.

  title={IL-6 is not essential for exercise-induced increases in glucose uptake.},
  author={Hayley M O'Neill and Rengasamy Palanivel and David G. Wright and Tara Macdonald and James S. V. Lally and Jonathan D Schertzer and Gregory R Steinberg},
  journal={Journal of applied physiology},
  volume={114 9},
Interleukin-6 (IL-6) increases glucose uptake in resting skeletal muscle. IL-6 is released from skeletal muscle during exercise; however; it is not known whether this IL-6 response is important for exercise-induced increases in skeletal muscle glucose uptake. We report that IL-6 knockout (KO) mice, 4 mo of age, have similar body weight to wild-type (WT), and, under resting conditions, oxygen consumption, food intake, substrate utilization, glucose tolerance, and insulin sensitivity are not… CONTINUE READING
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