IL-6 induces expression of the Fli-1 proto-oncogene via STAT3.

@article{Hodge2002IL6IE,
  title={IL-6 induces expression of the Fli-1 proto-oncogene via STAT3.},
  author={David R Hodge and Dapei Li and Sheng Mei Qi and William L. Farrar},
  journal={Biochemical and biophysical research communications},
  year={2002},
  volume={292 1},
  pages={
          287-91
        }
}
Induction of gene expression by IL-6 has become an area of intense interest due to the role this cytokine plays in mediating aspects of inflammation, cellular differentiation, and proliferation. The ETS family of transcription factors represents a group of positive and negative regulators of transcription, that are differentially expressed in a cell and tissue specific manner. The ETS protein Fli-1 is known to induce differentiation in the erythroblastic leukemia cell line K562 along… CONTINUE READING
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