IL-6 induces PI 3-kinase and nitric oxide-dependent protection and preserves mitochondrial function in cardiomyocytes.

@article{Smart2006IL6IP,
  title={IL-6 induces PI 3-kinase and nitric oxide-dependent protection and preserves mitochondrial function in cardiomyocytes.},
  author={Nicola Smart and Mart H. Mojet and D. S. Latchman and Michael Marber and Michael R Duchen and Richard John Heads},
  journal={Cardiovascular research},
  year={2006},
  volume={69 1},
  pages={164-77}
}
OBJECTIVE Interleukin-6 (IL-6) is a pro-inflammatory cytokine which is a prognostic marker associated with left ventricular contractile dysfunction and heart failure. On the other hand, IL-6 activates signalling pathways which mediate delayed ischemic preconditioning. We have therefore studied the cellular mechanisms of IL-6-induced cardioprotection. METHODS Inducible nitric oxide synthase (iNOS) expression, cardiomyocyte calcium handling, mitochondrial energetics, and the activation of… CONTINUE READING