IL-6-gp130-STAT3 in T cells directs the development of IL-17+ Th with a minimum effect on that of Treg in the steady state.

@article{Nishihara2007IL6gp130STAT3IT,
  title={IL-6-gp130-STAT3 in T cells directs the development of IL-17+ Th with a minimum effect on that of Treg in the steady state.},
  author={Mika Nishihara and Hideki Ogura and Naoko Ueda and Mineko Tsuruoka and Chika Kitabayashi and Fumio Tsuji and Hiroyuki Aono and Katsuhiko Ishihara and Eric S. Huseby and Ulrich A.K Betz and Masaaki Murakami and Toshio Hirano},
  journal={International immunology},
  year={2007},
  volume={19 6},
  pages={695-702}
}
IL-17-producing Th (Th17) comprise a distinct lineage of pro-inflammatory Th that are major contributors to autoimmune diseases. Treatment with IL-6 and transforming growth factor beta (TGFbeta) induces naive CD4+ T cells to generate Th17, which also requires expression of the IL-6/TGFbeta target RORgammat. We reported that IL-6 transduces two signaling pathways via tyrosine redidues of the signal transducer gp130: one depends on signal transducers and activators of transcription (STAT)-3… CONTINUE READING

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