IL-6 enhances the nuclear translocation of DNA cytosine-5-methyltransferase 1 (DNMT1) via phosphorylation of the nuclear localization sequence by the AKT kinase.

@article{Hodge2007IL6ET,
  title={IL-6 enhances the nuclear translocation of DNA cytosine-5-methyltransferase 1 (DNMT1) via phosphorylation of the nuclear localization sequence by the AKT kinase.},
  author={David R Hodge and Edward Cho and Terry D. Copeland and Tad Guszczynski and Eric X. Yang and A. K. Seth and William L. Farrar},
  journal={Cancer genomics & proteomics},
  year={2007},
  volume={4 6},
  pages={387-98}
}
The epigenetic programming of genomic DNA is accomplished, in part, by several DNA cytosine-5-methyltransferases that act by covalently modifying cytosines with the addition of a methyl group. This covalent modification is maintained by the DNA cytosine-5-methyltransferase-1 enzyme (DNMT1), which is capable of acting in concert with other similar enzymes to silence important tumor suppressor genes. IL-6 is a multifunctional mediator of inflammation, acting through several major signaling… CONTINUE READING

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