IL-6-deficient mice are resistant to experimental autoimmune encephalomyelitis: roles of IL-6 in the activation and differentiation of autoreactive T cells.

@article{Samoilova1998IL6deficientMA,
  title={IL-6-deficient mice are resistant to experimental autoimmune encephalomyelitis: roles of IL-6 in the activation and differentiation of autoreactive T cells.},
  author={Elena B. Samoilova and Jennifer L. Horton and Brendan Hilliard and Tong Liu and Yuhong Chen},
  journal={Journal of immunology},
  year={1998},
  volume={161 12},
  pages={6480-6}
}
Although autoreactive T cells recognizing self myelin Ags are present in most individuals, autoimmune disease of the central nervous system is a relatively rare medical condition. Development of autoimmune disease may require not only the presence of autoreactive T cells but also that autoreactive T cells become activated. Activation of T cells may require a minimum of two signals: an Ag-specific signal delivered by MHC-peptide complex and a second signal delivered by costimulatory molecules or… CONTINUE READING
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