IL-6 controls the innate immune response against Listeria monocytogenes via classical IL-6 signaling.

@article{Hoge2013IL6CT,
  title={IL-6 controls the innate immune response against Listeria monocytogenes via classical IL-6 signaling.},
  author={Judith Hoge and Isabell Yan and Nathalie J{\"a}nner and Val{\'e}a Schumacher and Athena Chalaris and Oliver M Steinmetz and Daniel Robert Engel and J{\"u}rgen Scheller and Stefan Rose-John and Hans-Willi Mittr{\"u}cker},
  journal={Journal of immunology},
  year={2013},
  volume={190 2},
  pages={703-11}
}
The cytokine IL-6 plays a protective role in immune responses against bacterial infections. However, the mechanisms of IL-6-mediated protection are only partially understood. IL-6 can signal via the IL-6R complex composed of membrane-bound IL-6Rα (mIL-6Rα) and gp130. Owing to the restricted expression of mIL-6Rα, classical IL-6 signaling occurs only in a limited number of cells such as hepatocytes and certain leukocyte subsets. IL-6 also interacts with soluble IL-6Rα proteins and these IL-6… CONTINUE READING
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Role of endogenously produced interleukin-6 as a second signal in murine thymocyte proliferation induced by multiple cytokines: regulatory effects of transforming growth factor-beta

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