IL-6 blocks a discrete early step in lymphopoiesis.

  title={IL-6 blocks a discrete early step in lymphopoiesis.},
  author={Kazuhiko Maeda and Yoshihiro Baba and Yoshinori Nagai and Kozo Miyazaki and Alexander Malykhin and Koji Nakamura and Paul W. Kincade and Nobuo Sakaguchi and K Mark Coggeshall},
  volume={106 3},
Animals lacking Src homology 2 domain-containing inositol 5-phosphatase (SHIP) display a reduction in lymphopoiesis and a corresponding enhancement of myelopoiesis. These effects are mediated at least in part by elevated levels of interleukin 6 (IL-6). Here, we show the lymphopoiesis block in SHIP-/- mice is due to suppression of the lymphoid lineage choice by uncommitted progenitors. The suppression can be reproduced in vitro with recombinant IL-6, and IL-6 acts directly on hematopoietic… CONTINUE READING


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