IL-6 blockade attenuates the development of murine sclerodermatous chronic graft-versus-host disease.

@article{Huu2012IL6BA,
  title={IL-6 blockade attenuates the development of murine sclerodermatous chronic graft-versus-host disease.},
  author={Doanh Le Huu and Takashi Matsushita and Guihua Jin and Yasuhito Hamaguchi and Minoru Hasegawa and Kazuhiko Takehara and M Fujimoto},
  journal={The Journal of investigative dermatology},
  year={2012},
  volume={132 12},
  pages={2752-61}
}
Systemic sclerosis (scleroderma) is a connective tissue disease characterized by excessive extracellular matrix deposition in the skin and visceral organs. Serum IL-6 levels are reported to be elevated in human scleroderma and chronic graft-versus-host disease (cGVHD) patients. IL-6 blockade using anti-IL-6 receptor mAb (anti-IL-6R mAb) results in amelioration of the pathologic symptoms of some autoimmune diseases such as rheumatoid arthritis and juvenile idiopathic arthritis. In this study, we… CONTINUE READING

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