IL-6 and high glucose synergistically upregulate MMP-1 expression by U937 mononuclear phagocytes via ERK1/2 and JNK pathways and c-Jun.

@article{Li2010IL6AH,
  title={IL-6 and high glucose synergistically upregulate MMP-1 expression by U937 mononuclear phagocytes via ERK1/2 and JNK pathways and c-Jun.},
  author={Yanchun Li and Devadoss John Samuvel and Kamala P. Sundararaj and Maria F. Lopes-Virella and Yan Huang},
  journal={Journal of cellular biochemistry},
  year={2010},
  volume={110 1},
  pages={248-59}
}
Matrix metalloproteinases (MMPs) play a pivotal role in tissue remodeling and destruction in inflammation-associated diseases such as cardiovascular disease and periodontal disease. Although it is known that interleukin (IL)-6 is a key proinflamatory cytokine, it remains unclear how IL-6 regulates MMP expression by mononuclear phagocytes. Furthermore, it remains undetermined how IL-6 in combination with hyperglycemia affects MMP expression. In the present study, we investigated the regulatory… CONTINUE READING
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