IL-6 and TNF-alpha synergistically inhibit allograft acceptance.

  title={IL-6 and TNF-alpha synergistically inhibit allograft acceptance.},
  author={Hua Shen and Daniel R Goldstein},
  journal={Journal of the American Society of Nephrology : JASN},
  volume={20 5},
Previous studies suggested that activation of the innate immune system impairs the induction of transplantation tolerance, but the responsible inflammatory mediators have not been identified. In this study, we examined whether IL-6 and TNF-alpha promote resistance to transplantation tolerance. Using a highly immunogenic murine skin allograft model, we found that the absence of both IL-6 and TNF-alpha in the graft recipient synergized with co-stimulatory blockade to induce tolerance. Furthermore… CONTINUE READING

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