IL-6 and TNF-Synergistically Inhibit Allograft Acceptance

  title={IL-6 and TNF-Synergistically Inhibit Allograft Acceptance},
  author={Hua Shen and Daniel R Goldstein},
Previous studies suggested that activation of the innate immune system impairs the induction of transplantation tolerance, but the responsible inflammatory mediators have not been identified. In this study, we examined whether IL-6 and TNFpromote resistance to transplantation tolerance. Using a highly immunogenic murine skin allograft model, we found that the absence of both IL-6 and TNFin the graft recipient synergized with co-stimulatory blockade to induce tolerance. Furthermore, IL-6 and… CONTINUE READING
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