IL-6 and TNF-α induced obesity-related inflammatory response through transcriptional regulation of miR-146b.

  title={IL-6 and TNF-α induced obesity-related inflammatory response through transcriptional regulation of miR-146b.},
  author={Chunmei Shi and Lijun Zhu and X Chen and Nan Gu and Ling Chen and Lu Zhu and Lei Yang and Lingxia Pang and Xi-rong Guo and Chen-bo Ji and Chunmei Zhang},
  journal={Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research},
  volume={34 5},
Obesity is associated with a low-grade inflammation of white adipose tissue, which can subsequently lead to insulin resistance, impaired glucose tolerance, and even diabetes. MicroRNAs (miRNAs) have been implicated as negative regulators controlling diverse biological processes at the level of post-transcriptional repression. miR-146b is an intergenic miRNA that can regulate the inflammatory process by attenuating cytokine signaling via the nuclear factor-κB pathway. In this study, we focused… CONTINUE READING
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