IL-6 and IL-1 enhance the accessory activity of human blood monocytes during differentiation to macrophages.

@article{Ruppert1991IL6AI,
  title={IL-6 and IL-1 enhance the accessory activity of human blood monocytes during differentiation to macrophages.},
  author={John Ruppert and John A. Peters},
  journal={Journal of immunology},
  year={1991},
  volume={146 1},
  pages={144-9}
}
The role of IL-6 and IL-1 in the regulation of accessory activity and differentiation in the human monocyte/macrophage (Mo/Mph) system was investigated. IL-6 combined with IL-1 had a strong effect on the accessory activity of Mo-derived cells dependent on their state of differentiation in vitro. Fresh Mo prepared from peripheral blood differentiated into potent accessory cells in vitro within 24 h in the absence of exogenous triggers in serum-containing and serum-free medium. Mo cultured for 2… CONTINUE READING