IL-6 Trans-Signaling Enhances CCL20 Production from IL-1β-Stimulated Human Periodontal Ligament Cells

Abstract

CC chemokine ligand 20 (CCL20) plays a central role in the recruitment of CCR6-expressing cells, including Th17 cells which are related to bone resorption in periodontal lesions and thus in the development of periodontal disease. IL-6 is an important cytokine that is associated with the pathogenesis of periodontitis. However, the effect of IL-6 on CCL20… (More)
DOI: 10.1007/s10753-013-9750-8

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