IL-6-Dependent PGE2 Secretion by Mesenchymal Stem Cells Inhibits Local Inflammation in Experimental Arthritis

@inproceedings{Bouffi2010IL6DependentPS,
  title={IL-6-Dependent PGE2 Secretion by Mesenchymal Stem Cells Inhibits Local Inflammation in Experimental Arthritis},
  author={Carine Bouffi and Claire Bony and Gabriel Courties and Christian Jorgensen and Dani{\'e}le No{\"e}l},
  booktitle={PloS one},
  year={2010}
}
BACKGROUND Based on their capacity to suppress immune responses, multipotent mesenchymal stromal cells (MSC) are intensively studied for various clinical applications. Although it has been shown in vitro that the immunomodulatory effect of MSCs mainly occurs through the secretion of soluble mediators, the mechanism is still not completely understood. The aim of the present study was to better understand the mechanisms underlying the suppressive effect of MSCs in vivo, using cells isolated from… CONTINUE READING

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