IL-6/IL-6 receptor system and its role in physiological and pathological conditions.

  title={IL-6/IL-6 receptor system and its role in physiological and pathological conditions.},
  author={Masahiko Mihara and Misato Hashizume and Hiroto Yoshida and Miho Suzuki and Masashi Shiina},
  journal={Clinical science},
  volume={122 4},
IL (interleukin)-6, which was originally identified as a B-cell differentiation factor, is a multifunctional cytokine that regulates the immune response, haemopoiesis, the acute phase response and inflammation. IL-6 is produced by various types of cell and influences various cell types, and has multiple biological activities through its unique receptor system. IL-6 exerts its biological activities through two molecules: IL-6R (IL-6 receptor) and gp130. When IL-6 binds to mIL-6R (membrane-bound… 

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