IL-5 secretion by allergen-stimulated CD4+ T cells in primary culture: relationship to expression of allergic disease.

@article{Till1997IL5SB,
  title={IL-5 secretion by allergen-stimulated CD4+ T cells in primary culture: relationship to expression of allergic disease.},
  author={Stephen John Till and Richard R. Dickason and David W. Huston and Marc Humbert and D Robinson and Mark Larch{\'e} and Stephen R. Durham and Antony B. Kay and Chris J. Corrigan},
  journal={The Journal of allergy and clinical immunology},
  year={1997},
  volume={99 4},
  pages={563-9}
}
BACKGROUND IL-5-producing allergen-specific T cells are thought to play a prominent role in the pathogenesis of allergic inflammation. We hypothesized that T cell allergen-driven IL-5 synthesis is elevated in patients with atopic disease as compared with that in atopic patients free of disease and nonatopic control subjects. OBJECTIVES The purpose of this study was to compare IL-5 and interferon-gamma (IFN-gamma) secretion and proliferation by peripheral blood T cells from sensitized atopic… CONTINUE READING

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