IL-5-deficient mice have a developmental defect in CD5+ B-1 cells and lack eosinophilia but have normal antibody and cytotoxic T cell responses.

@article{Kopf1996IL5deficientMH,
  title={IL-5-deficient mice have a developmental defect in CD5+ B-1 cells and lack eosinophilia but have normal antibody and cytotoxic T cell responses.},
  author={Manfred Kopf and Frank Brombacher and Philip D. Hodgkin and Alistair J Ramsay and E A Milbourne and Wen Juan Dai and K. S. Ovington and Carolyn A. Behm and G. W. K{\"o}hler and Ian G. Young and Klaus Ingo Matthaei},
  journal={Immunity},
  year={1996},
  volume={4 1},
  pages={15-24}
}
Mice deficient in interleukin-5 (IL-5-/- mice) were generated by gene targeting in embryonal stem cells. Contrary to previous studies, no obligatory role for IL-5 was demonstrated in the regulation of conventional B (B-2) cells, in normal T cell-dependent antibody responses or in cytotoxic T cell development. However, CD5+ B cells (B-1 cells) in the peritoneal cavity were reduced by 50%-80% in 2-week-old IL-5-/- mice, returning to normal by 6-8 weeks of age. The IL-5-/- mice did not develop… CONTINUE READING

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